NADPH-Cytochrome P450 Reductase



NADPH-Cytochrome P450 Reductase (P450r) is the electron donor for several oxygenase enzymes including Cytochrome P450. The images at the left and at the right correspond to one representative P450r, i.e. the crystal structure of NADPH-Cytochrome P450 Reductase (1b1c).

P450r
1bpo - yP450r (mutant) - yeast

2bf4, 2bn4 - yP450r

3es9, 1ja0 - rP450r - rat

1j9z, 1ja1, 3ojw, 3ojx - rP450r (mutant)

P450r BM3 heme domain
3npl, 3kx3, 3kx4, 3kx5, 3hf2, 3dgi, 3ekb, 3ekd, 3ekf, 3cbd, 2nnb, 1zo4, 1yqo, 1yqp, 1smi, 1p0v, 1p0w, 1p0x, 1jme – BmP450r BM3 heme domain (mutant) – Bacillus megaterium

2ij2 - BmP450r BM3 heme domain

2uwh, 1zo9, 1zoa, 1smj - BmP450r BM3 heme domain (mutant)+palmitate derivative

1jpz - BmP450r BM3 heme domain +palmitate derivative

3ben - BmP450r BM3 heme domain +imidazole derivative

2j4s, 2j1m - BmP450r BM3 heme domain + DMSO

P450r FMN-binding domain
1b1c - hP450r FMN-binding domain - human

3fjo – yP450r FMN-binding domain/hP450r FAD domain

P450r hydrophilic domain
1amo - rP450r hydrophilic domain